Steroid 5-alpha-reductase 2 deficiency

The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
 

Hey Rob,
very interesting article, thanks for sharing all this!
I was wondering why you haven’t mentioned anything about the 5a-reductase inhibitory effects of curcumin as studied in following research:
https:///pmc/articles/PMC4618860/
Based on this study the inhibitory effects of curcumin seems to be even greater than Finasteride. Have you heard about it before?
I came across this study when I was thinking of starting a morning routine of taking a daily shot of apple cider vinegar, lemon, ginger, TURMERIC and cayenne pepper mixture (look it up, great stuff).

There are also some who complain of joint pain when using Winstrol. As a steroid that does not aromatize there will be no water retention but the “dry feeling” may not be what many think it is. Most who use the steroid will be physique athletes or gym rats during a cutting phase. They will also typically add it into a plan late in the diet once they’re already lean. Typically, when you become very lean, bodybuilding lean, this makes the joints a little uncomfortable. With or without Winstrol this discomfort could potentially exist. As for pro athletes who have nearly every last steroid at their disposal, remember, if Winstrol weren’t effective in competitive sports so many athletes wouldn’t make it a primary and favorite choice. In fact, the combo of Winstrol with low doses of Nandrolone is a very common stack among many athletes, and this stack will greatly eliminate any potential joint discomfort should it exist.

The disorder has been found in blacks, whites, American Indians, and Latin Americans, as well as in families from Malta, Jordan, and Pakistan. Imperato-McGinley et al. (1991) described a cluster of male pseudohermaphrodites in the Simbari Anga linguistic group in the Eastern Highlands of Papua New Guinea. Their studies revealed a phenotypic and biochemical profile similar to that in patients studied in the Dominican Republic, except for a greater abundance of facial and body hair. DHT is responsible for masculinization of the external genitalia of the fetus and for masculinization at puberty. The virilization at puberty in PPSH may be related to the facts that the reductase is not completely absent and that low levels of DHT are found in plasma.

Steroid 5-alpha-reductase 2 deficiency

steroid 5-alpha-reductase 2 deficiency

The disorder has been found in blacks, whites, American Indians, and Latin Americans, as well as in families from Malta, Jordan, and Pakistan. Imperato-McGinley et al. (1991) described a cluster of male pseudohermaphrodites in the Simbari Anga linguistic group in the Eastern Highlands of Papua New Guinea. Their studies revealed a phenotypic and biochemical profile similar to that in patients studied in the Dominican Republic, except for a greater abundance of facial and body hair. DHT is responsible for masculinization of the external genitalia of the fetus and for masculinization at puberty. The virilization at puberty in PPSH may be related to the facts that the reductase is not completely absent and that low levels of DHT are found in plasma.

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